The purpose of a new study published in Biomed Research International was to evaluate the in vitro interactions between lipoproteins of Mycoplasma and Ureaplasma species - implicated in bacterial vaginosis (BV), and vaginal lineage (HMVII) cells and to study the effect of Lactobacillus isolates from cocoa fermentation on these interactions. The findings of this experiment revealed that Lactobacillus strains have some important probiotic characteristics, with autoaggregation percentages of 28.55% and 31.82% for L. fermentum FA4 and L. plantarum PA3 strains, respectively, and percent adhesion values of 31.66 and 41.65%, respectively. The two strains were hydrophobic, with moderate to high hydrophobicity values, 65.33% and 71.12% for L. fermentum FA4 and L. plantarum PA3 in toluene. Both strains secreted acids into the culture medium with pH 4.32 and pH 4.33, respectively, and showed antibiotics susceptibility profiles comparable to other lactobacilli. Additionally, the strains were able to inhibit the death of vaginal epithelial cells after incubation with U. parvum lipid-associated membrane proteins (LAMP) from 41.03% to 2.43% (L. fermentum FA4) and 0.43% (L. plantarum PA3) and could significantly decrease the rate of cell death caused by the interaction with LAMP of M. hominis from 34.29% to 14.06% (L. fermentum FA4) and 14.61% (L. plantarum PA3). Hence, these strains demonstrated the potential for maintaining a healthy vaginal environment.